Which of the following is a contraindication for fibrinolytic therapy?

Fibrinolytic therapy is a treatment used to dissolve blood clots in conditions such as myocardial infarction. However, it carries significant risks, particularly in individuals with a history of certain conditions. A history of stroke, especially a hemorrhagic stroke, is a critical contraindication for fibrinolytic therapy because these patients are at a substantially increased risk for re-bleeding within the cerebral vasculature. The use of fibrinolytic agents in these individuals can provoke life-threatening complications, such as intracranial hemorrhage.

In contrast, minor head trauma might still allow the use of fibrinolytic therapy, provided that there are no signs of intracranial bleeding. Myocardial infarction is the condition fibrinolytics are intended to treat, and recent surgery does not inherently contraindicate the use of fibrinolytics but requires careful consideration based on the nature of the surgery and the timing. Therefore, the presence of a history of stroke is the most significant concern when considering fibrinolytic therapy and thus serves as a clear contraindication.